VVD-214 free base · Synonyms: VVD-133214 | RO7589831

VVD-133214 is a covalent allosteric inhibitor of WRN.

For research use only. Not for human or veterinary use.

Target DNA/RNA Synthesis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

VVD-214 structure

CAS No.: 3026500-20-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 480.00	BP-00122-100mg	In stock	Get quote
250 mg	USD 780.00	BP-00122-250mg	In stock	Get quote
500 mg	USD 1,180.00	BP-00122-500mg	In stock	Get quote
1 g	USD 1,680.00	BP-00122-1g	In stock	Get quote
5 g	Inquire	BP-00122-5g	Inquire	Inquire

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Description

VVD-133214 is a covalent allosteric inhibitor of WRN. It selectively engages a cysteine (C727). VVD-133214 binds WRN protein cooperatively with nucleotide. VVD-133214 can be used for MSI-H cancers study.

Biological activity

VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.

Specifications

MW (average): 437.4600
Formula: C₂₀H₂₁F₂N₃O₄S
CAS No.: 3026500-20-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Baltgalvis KA, Lamb KN, Symons KT, et al. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature. Published online April 24, 2024. doi:10.1038/s41586-024-07318-y

[2]. Kikuchi S, et al. Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase[J]. Cancer Research, 2024, 84(7_Supplement): ND11-ND11.

Same target

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