α-Tocopherol phosphate (disodium) salt form · phosphate · Parent α-Tocopherol phosphate (disodium)

α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin…

For research use only. Not for human or veterinary use.

Target Apoptosis Reactive Oxygen Species (ROS)

Research area Cardiovascular Disease Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

α-Tocopherol phosphate (disodium) structure

CAS No.: 60934-46-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 340.00	BP-02402A-100mg	In stock	Get quote
250 mg	USD 680.00	BP-02402A-250mg	In stock	Get quote
500 mg	USD 1,090.00	BP-02402A-500mg	In stock	Get quote
1 g	USD 1,740.00	BP-02402A-1g	In stock	Get quote
2 g	USD 2,785.00	BP-02402A-2g	In stock	Get quote
3 g	USD 3,342.00	BP-02402A-3g	In stock	Get quote
5 g	Inquire	BP-02402A-5g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity .

Biological activity

In Vitro α-Tocopherol phosphate disodium (100 μM, 24 h) inhibits high Glucose (HY-B0389)/ischemic-induced apoptosis and migration in endothelial progenitor cells, promotes capillary-like tube formation through regulation of Bcl-2, Akt, NF-κB, p38MAPK and JNK expressions. In Vivo α-Tocopherol phosphate disodium (100 μM, intramuscular, single dose) exhibits angiogenesis-promoting activity in Streptozotocin (HY-13753) and ligation induced rats type 2 diabetes and ischemia models.

Identifiers

SMILES: CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OP(O[Na])(O[Na])=O)=C1C)C
InChIKey: LPWACMVJQSCQOF-RQGAJXLPSA-L

Specifications

MW (average): 554.6497
Formula: C₂₉H₄₉Na₂O₅P
CAS No.: 60934-46-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture and light

Solubility

Soluble in DMSO : 4 mg/mL

Documents

References

[1].Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400.

[2].Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.

Same target

Search Apoptosis

Same research area

Search Cardiovascular Disease