CFT1946 free base · Synonyms: CFT-1946 · CFT 1946
CFT1946 is an orally active and selective target ligand.
For research use only. Not for human or veterinary use.
CFT1946 structure
CAS No.: 2882165-79-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 798.00 | BP-02369-25mg | In stock | Get quote |
| 50 mg | USD 1,398.00 | BP-02369-50mg | In stock | Get quote |
| 100 mg | USD 2,280.00 | BP-02369-100mg | In stock | Get quote |
| 250 mg | Inquire | BP-02369-250mg | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
CFT1946 is an orally active and selective target ligand for BRAF kinase. CFT1946 is a degrader of mutant BRAFV600E, G469A, G466V and p61-BRAFV600E. CFT1946 can be used in tumor research.
Biological activity
Tagarafdeg (CFT1946) (100 nM; 24 h) causes BRAFV600E degradation and inhibits MAPK Signaling with pERK loss in BRAFV600E cells but not in WT-BRAF cells Tagarafdeg (CFT1946) (0.3-10 mg/kg; PO; BID; 20 days) induces tumor regression in the BRAFV600E A375 xenograft mouse model with 10 mg/kg
Identifiers
- SMILES
-
CN1C(C(C(N(CCC2=O)C(N2)=O)=N1)=C3)=CC(N(CC4)CCC4(O)CC(N5CCC6(C[C@@H](N(C=NC7=CC=C8OC(C(F)=CC=C9N[S](N(C)CC)(=O)=O)=C9C#N)C(C7=C8)=O)CO6)CC5)=O)=C3F - InChIKey
-
OCDRMYDQTIPVOI-HHHXNRCGSA-N
Specifications
- MW (average)
- 958.0010
- Formula
- C45H49F2N11O9S
- CAS No.
- 2882165-79-7
- Physical state
- Solid
- Color
- Off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 100 mg/mL