S55746 free base · Synonyms: S55746 free base | BLC-201

S55746 is a potent, orally active and selective BCL-2 inhibitor.

For research use only. Not for human or veterinary use.

Target Bcl-2 Family

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

S55746 structure

CAS No.: 1448584-12-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 598.00	BP-02355-50mg	In stock	Get quote
100 mg	USD 898.00	BP-02355-100mg	In stock	Get quote
250 mg	USD 1,685.00	BP-02355-250mg	In stock	Get quote
500 mg	Inquire	BP-02355-500mg	In stock	Inquire
1 g	Inquire	BP-02355-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity.

Biological activity

S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity.

Identifiers

SMILES: O=C(C1=C2CCCCN2C(C3=C(C(N4CC5=C(C=CC=C5)C[C@H]4CN6CCOCC6)=O)C=C(OCO7)C7=C3)=C1)N(C8=CC=C(O)C=C8)C9=CC=CC=C9
InChIKey: VYXJULKGMXJVGI-XIFFEERXSA-N

Specifications

MW (average): 710.8168
Formula: C₄₃H₄₂N₄O₆
CAS No.: 1448584-12-0
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 75 mg/mL

Documents

References

[1] Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018, 9(28):20075-20088.

Same target

Search Bcl-2 Family

Same research area

Search Cancer