AOH1996 free base · Synonyms: AOH-1996 · AOH 1996

AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict…

For research use only. Not for human or veterinary use.

Target PDAC KRAS

Research area Cancer

Purity >99% Stock Inquire

Data Sheet SDS COA

AOH1996 structure

CAS No.: 2089314-64-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 288.00	BP-01969-1g	In stock	Get quote
5 g	USD 1,152.00	BP-01969-5g	In stock	Get quote
10 g	USD 1,752.00	BP-01969-10g	In stock	Get quote
25 g	Inquire	BP-01969-25g	Inquire	Inquire

Need another size or custom synthesis? Request a quote.

Description

AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict (TRC).

Biological activity

In vitro Seven AML cell lines and primary CD34+CD38- leukemic stem cells (LSC) were treated with AOH1996 at concentrations of 0.5–1 μM for 24 hours, and cell proliferation, apoptosis, and colony formation assays were performed. AOH1996 dose-dependently inhibited proliferation and colony formation of AML cells and LSC, induced apoptosis, and had no significant effect on normal CD34+CD38- hematopoietic stem cells. In vivo Human primary AML cells were transplanted into Es1(ko)SCID mice, and 7 days later, AOH1996 (100 mg/kg) was administered by oral gavage twice daily for 3 weeks. AOH1996 significantly reduced leukemia burden in peripheral blood and spleen, and extended median survival from 35 days to 50 days; secondary transplantation confirmed reduced LSC burden, with survival extended from 30 days to 42 days.

Identifiers

SMILES: O=C(NCC(NC1=C(C=CC=C1)OC2=CC=CC(OC)=C2)=O)C3=CC=CC4=C3C=CC=C4
InChIKey: HDMONPHKMIZXDH-UHFFFAOYSA-N

Specifications

MW (average): 426.4639
Formula: C₂₆H₂₂N₂O₄
CAS No.: 2089314-64-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Gu, Long et al. “Small molecule targeting of transcription-replication conflict for selective chemotherapy.” Cell chemical biology, S2451-9456(23)00221-0. 26 Jul. 2023

[2]. Gu L, et al. Pharmacological targeting of transcription-replication conflict leads to anti-cancer efficacy with minimal side effects in preclinical models[J]. Cancer Research, 2021, 81(13_Supplement): 1269-1269.

Same research area

Search Cancer