Lonafarnib free base · Synonyms: SCH66336
Lonafarnib is an orally bioavailable FPTase inhibitor.
For research use only. Not for human or veterinary use.
Lonafarnib structure
CAS No.: 193275-84-2
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 750.00 | BP-02337-250mg | In stock | Get quote |
| 500 mg | USD 1,350.00 | BP-02337-500mg | In stock | Get quote |
| 1 g | USD 2,150.00 | BP-02337-1g | In stock | Get quote |
| 2 g | Inquire | BP-02337-2g | In stock | Inquire |
| 5 g | Inquire | BP-02337-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively.
Biological activity
Lonafarnib (SCH 66336) is a selectively farnesyl protein transferase (FPT) inhibitor, inhibiting H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib (8 μM) suppresses PKB/Akt activity as well as the phosphorylation of the Akt substrates glycogen synthase kinase (GSK)-3β, forkhead transcription factor, and BAD in SqCC/Y1 cells. Lonafarnib induces a CCAAT/enhancer-binding protein homologous protein (CHOP)-dependent transactivation of the DR5 promoter, thus induces CHOP-dependent DR5 up-regulation.
Identifiers
- SMILES
-
NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2C3=C(CCC4=C2C(Br)=CC(Cl)=C4)C=C(Br)C=N3)CC1 - InChIKey
-
DHMTURDWPRKSOA-RUZDIDTESA-N
Specifications
- MW (average)
- 638.8220
- Formula
- C27H31Br2ClN4O2
- CAS No.
- 193275-84-2
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO