S55746 hydrochloride salt form · hydrochloride · Parent S55746 · Synonyms: BCL-201 hydrochloride

S55746 is a potent, orally active and selective BCL-2 inhibitor.

For research use only. Not for human or veterinary use.

Target Bcl-2 Family

Research area Cancer

Purity 98+% Stock Inquire

Data Sheet SDS COA

S55746 hydrochloride structure

CAS No.: 1448525-91-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 598.00	BP-02355A-250mg	In stock	Get quote
500 mg	USD 998.00	BP-02355A-500mg	In stock	Get quote
1 g	USD 1,798.00	BP-02355A-1g	In stock	Get quote
2 g	USD 2,998.00	BP-02355A-2g	In stock	Get quote
5 g	Inquire	BP-02355A-5g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Related forms

BP-02355 — S55746

Description

S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity.

Biological activity

S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity.

Identifiers

SMILES: O=C(N(C1=CC=CC=C1)C2=CC=C(C=C2)O)C3=C4CCCCN4C(C5=C(C=C6OCOC6=C5)C(N7CC8=C(C[C@H]7CN9CCOCC9)C=CC=C8)=O)=C3.Cl
InChIKey: RAUZIGXCAJHBEL-WAQYZQTGSA-N

Specifications

MW (average): 747.2780
Formula: C₄₃H₄₃ClN₄O₆
CAS No.: 1448525-91-4
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45(3):744-7.

[2]. Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2(12):1265-72.

[3]. Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114(10):2392-404.

Same target

Search Bcl-2 Family

Same research area

Search Cancer