CDDO-dhTFEA free base · Synonyms: RTA dh404
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
For research use only. Not for human or veterinary use.
CDDO-dhTFEA structure
CAS No.: 1191265-33-4
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 395.00 | BP-01847-25mg | In stock | Get quote |
| 50 mg | USD 550.00 | BP-01847-50mg | In stock | Get quote |
| 100 mg | USD 795.00 | BP-01847-100mg | In stock | Get quote |
| 250 mg | USD 1,180.00 | BP-01847-250mg | In stock | Get quote |
| 500 mg | USD 1,650.00 | BP-01847-500mg | In stock | Get quote |
| 1 g | Inquire | BP-01847-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
Biological activity
CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.
Identifiers
- SMILES
-
CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@]2([C@]13[H])[H])C)C(NCC(F)(F)F)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)[C@@]4([H])CC3=O)=O - InChIKey
-
RMYWYZJDSBWZHH-BFGQVZSYSA-N
Specifications
- MW (average)
- 574.7172
- Formula
- C33H45F3N2O3
- CAS No.
- 1191265-33-4
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO 100 mg/mL