VS-4718 free base · Synonyms: PND1186 | SR-2516

PND-1186 is a reversible and selective FAK inhibitor.

For research use only. Not for human or veterinary use.

Target FAK Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

VS-4718 structure

CAS No.: 1061353-68-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 280.00	BP-02306-500mg	In stock	Get quote
1 g	USD 550.00	BP-02306-1g	In stock	Get quote
2 g	USD 880.00	BP-02306-2g	In stock	Get quote
3 g	USD 1,056.00	BP-02306-3g	In stock	Get quote
5 g	USD 1,400.00	BP-02306-5g	In stock	Get quote
10 g	USD 2,250.00	BP-02306-10g	In stock	Get quote

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Description

PND-1186 (VS-4718, SR-2156) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. PND-1186 (VS-4718) selectively promotes tumor cell apoptosis.

Biological activity

In Vitro PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 μM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h. In Vivo PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis.

Identifiers

SMILES: CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(C=C2OC)N2CCOCC2)=NC=C1C(F)(F)F
InChIKey: IGUBBWJDMLCRIK-UHFFFAOYSA-N

Specifications

MW (average): 501.5008
Formula: C₂₅H₂₆F₃N₅O₃
CAS No.: 1061353-68-1
Physical state: Solid
Color: White to gray
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Tanjoni, Isabelle et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer biology & therapy vol. 9,10 (2010): 764-77.

Same target

Search FAK

Same research area

Search Cancer