NDI-034858 free base · Synonyms: Zasocitinib | TAK-279

NDI-034858 is a TYK2 inhibitor.

For research use only. Not for human or veterinary use.

Target JAK

Research area Inflammation/Immunology

Purity >99.5% SFC Stock Inquire

Data Sheet COA

NDI-034858 structure

CAS No.: 2272904-53-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 480.00	BP-01998-250mg	In stock	Get quote
500 mg	USD 820.00	BP-01998-500mg	In stock	Get quote
1 g	USD 1,320.00	BP-01998-1g	In stock	Get quote
2 g	Inquire	BP-01998-2g	Inquire	Inquire

Need another size or custom synthesis? Request a quote.

Description

NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.

Biological activity

Zasocitinib (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively Zasocitinib inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell

Identifiers

SMILES: CO[C@H](CC1)[C@@H]1NC(C2=C3N(N=C2)C(NC)=CC(NC4=CC=CN(C5=CC=CC=N5)C4=O)=N3)=O
InChIKey: BWINBHTTZLVXGT-NVXWUHKLSA-N

Specifications

MW (average): 460.4885
Formula: C₂₃H₂₄N₈O₃
CAS No.: 2272904-53-5
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 50 mg/mL

Documents

References

[1]. Leit, Silvana et al. “Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.” Journal of medicinal chemistry vol. 66,15 (2023): 10473-10496.

[2]. Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.

Same target

Search JAK

Same research area

Search Inflammation/Immunology