BMS-986463 free base · Synonyms: BMS 986463 · BMS986463

BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader.

For research use only. Not for human or veterinary use.

Target Molecular Glues Wee1

Research area Inflammation/Immunology Cancer

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Data Sheet SDS COA

BMS-986463 structure

CAS No.: 3025467-07-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 550.00	BP-02278-10mg	In stock	Get quote
25 mg	USD 798.00	BP-02278-25mg	In stock	Get quote
50 mg	USD 985.00	BP-02278-50mg	In stock	Get quote
100 mg	USD 1,595.00	BP-02278-100mg	In stock	Get quote
250 mg	USD 2,985.00	BP-02278-250mg	In stock	Get quote
500 mg	Inquire	BP-02278-500mg	In stock	Inquire

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Description

BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research.

Biological activity

In Vitro The WEE1 tyrosine kinase is an essential cell cycle regulator whose primary role is to inhibit cell cycle progression during the S and G2/M phases to prevent mitotic division of cells with DNA damage

Identifiers

SMILES: O=C1CC[C@@H](C(N1)=O)N2CC3=CC(O[C@H]4CCN(C4)CC5=CC(F)=C6N=C(C=CC6=C5)C7CCOCC7)=CC=C3C2=O
InChIKey: JPTNRZBZSUZXCS-CUBQBAPOSA-N

Specifications

MW (average): 572.6266
Formula: C₃₂H₃₃FN₄O₅
CAS No.: 3025467-07-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO

In vitro: DMSO : 2 mg/mL

Documents

References

[1]. Jennifer R, et al. Discovery of a first-in-class molecular glue degrader of WEE1 kinase, BMS-986463, for the treatment of advanced malignant solid tumors. ACS. 2025 Aug 20.

Same target

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Same research area

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