AGI-43192 free base · Synonyms: AGI 43192 · AGI43192

AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A.

For research use only. Not for human or veterinary use.

Target Methionine Adenosyltransferase (MAT)

Research area Neurological Disease Cancer

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Data Sheet SDS COA

AGI-43192 structure

CAS No.: 2377491-54-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 785.00	BP-02237-100mg	In stock	Get quote
250 mg	USD 1,184.00	BP-02237-250mg	In stock	Get quote
500 mg	USD 1,685.00	BP-02237-500mg	In stock	Get quote
1 g	USD 2,585.00	BP-02237-1g	In stock	Get quote
2 g	Inquire	BP-02237-2g	In stock	Inquire

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Description

AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 has the potential for research of cancer disease.

Biological activity

AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease.

Identifiers

SMILES: O=C1C(C2=CC=C(Cl)C=C2)=C3N=C(NCC(F)(F)F)N=CC3=CN1C4=CC5=CN(C)N=C5C=C4
InChIKey: XXCYDSDPIJJBSI-UHFFFAOYSA-N

Specifications

MW (average): 484.8610
Formula: C₂₃H₁₆ClF₃N₆O
CAS No.: 2377491-54-6
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 13.89 mg/mL

Documents

References

[1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.

Same target

Search Methionine Adenosyltransferase (MAT)

Same research area

Search Neurological Disease