Atebimetinib free base

Atebimetinib is a novel orally dual-MEK inhibitor.

For research use only. Not for human or veterinary use.

Target MEK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Atebimetinib structure

CAS No.: 2669009-92-9

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 650.00	BP-02277-10mg	In stock	Get quote
25 mg	USD 1,150.00	BP-02277-25mg	In stock	Get quote
50 mg	USD 1,850.00	BP-02277-50mg	In stock	Get quote
100 mg	USD 2,950.00	BP-02277-100mg	In stock	Get quote
250 mg	Inquire	BP-02277-250mg	In stock	Inquire
500 mg	Inquire	BP-02277-500mg	In stock	Inquire

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Description

Atebimetinib (IMM-1-104) is a novel orally dual-MEK inhibitor with anti-pancreatic cancer activity.

Biological activity

In Vivo Atebimetinib (IMM-1-104) and sotorasib were well-tolerated as single agents and in combination with each other across all dose levels tested. Both drugs demonstrated dose-dependent antitumor activity with tumor regressions noted at higher dose levels. Atebimetinib in combination with sotorasib produced deep regressions that were sustained longer than either drug alone.

Identifiers

SMILES: O=C1OC=2C=C(OC(=O)N(C)C)C=CC2C(=C1CC=3C=CC=C(NS(=O)(=O)NC)C3F)CN(C)C
InChIKey: VGDONWMTHHBKMZ-UHFFFAOYSA-N

Specifications

MW (average): 506.5470
Formula: C₂₃H₂₇FN₄O₆S
CAS No.: 2669009-92-9
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years, 4°C, 2 years; In solvent -20°C, 1 month.

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Peter J. King, et al. Benchmarking the novel dual-MEK inhibitor, IMM-1-104, head-to-head and in combination with sotorasib (AMG-510) in the MIA PaCa-2 (KRAS-G12C) pancreatic cancer xenograft model. Mol Cancer Ther (2021) 20 (12_Supplement): P240.

Same research area

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