BGB-8035 free base · Synonyms: BGB 8035 · BGB8035

BGB-8035 is an orally active, highly selective bruton's tyrosine kinase inhibitor.

For research use only. Not for human or veterinary use.

Target Btk

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BGB-8035 structure

CAS No.: 2283349-24-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 498.00	BP-02261-50mg	In stock	Get quote
100 mg	USD 898.00	BP-02261-100mg	In stock	Get quote
250 mg	USD 1,685.00	BP-02261-250mg	In stock	Get quote
500 mg	USD 2,785.00	BP-02261-500mg	In stock	Get quote
1 g	Inquire	BP-02261-1g	In stock	Inquire
5 g	Inquire	BP-02261-5g	In stock	Inquire

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Description

BGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1.1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively. BGB-8035 has antitumor and anti-arthritis activity

Biological activity

Identifiers

SMILES: NC(C1=C2N(N=C1C3=CC(OC)=C(C(OC)=C3)C)[C@H](C4CCN(CC4)C(C=C)=O)CCN2)=O
InChIKey: ZFDGMDVYMNWICG-KRWDZBQOSA-N

Specifications

MW (average): 453.5340
Formula: C₂₄H₃₁N₅O₄
CAS No.: 2283349-24-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 50 mg/mL

Documents

References

[1]. Yunhang Guo, et al. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 23;66(6):4025-4044.

Same target

Search Btk

Same research area

Search Inflammation/Immunology