Zongertinib free base · Synonyms: BI-1810631 | BI 1810631

Zongertinib is a potent and selective HER2 and EGFR tyrosine kinase inhibitor.

For research use only. Not for human or veterinary use.

Target c-Met/HGFR

Research area Cancer

Purity >99% Stock Inquire

Data Sheet SDS COA

Zongertinib structure

CAS No.: 2728667-27-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 635.00	BP-02255-1g	In stock	Get quote
5 g	USD 2,262.00	BP-02255-5g	In stock	Get quote
10 g	USD 3,676.00	BP-02255-10g	In stock	Get quote

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Description

Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors.

Biological activity

Zongertinib in NCI-H-2170 HER2 wt amp, NCI-H2170 HER2 YVMA, A431 EGFR wt amp, BAF3 HER2 WT, BAF3 HER2 YVMA and BAF3 EGF dep. The IC50 values that inhibits cell proliferation are 6 nM, 33 nM, >5000 nM, 1 nM, 16 nM, and 1540 nM, respectively

Identifiers

SMILES: CC1=C(C=CC(=C1)NC2=NC=NC3=CN=C(N=C32)N4CCC(CC4)NC(=O)C=C)OC5=CC6=C(C=C5)N(C=N6)C
InChIKey: YSGNGFPNTLERCR-UHFFFAOYSA-N

Specifications

MW (average): 535.5997
Formula: C₂₉H₂₉N₉O₂
CAS No.: 2728667-27-2
Physical state: Solid
Color: Light yellow to green yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 30.77 mg/mL

Documents

References

[1]. WHO Drug Informat ion - World Health Organization (WHO).

[2]. Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.

[3]. Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899.

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