Tolebrutinib free base · Synonyms: SAR442168 | PRN2246
Tolebrutinib is a potent, selective and brain-penetrant BTK inhibitor.
For research use only. Not for human or veterinary use.
Tolebrutinib structure
CAS No.: 1971920-73-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 485.00 | BP-01956-250mg | In stock | Get quote |
| 500 mg | USD 785.00 | BP-01956-500mg | In stock | Get quote |
| 1 g | USD 1,250.00 | BP-01956-1g | In stock | Get quote |
| 5 g | Inquire | BP-01956-5g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Tolebrutinib (SAR442168) is a potent, selective and brain-penetrant BTK inhibitor, with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
Biological activity
Tolebrutinib (SAR442168, PRN2246) is a potent, selective and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
Identifiers
- SMILES
-
C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=NC=C3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5 - InChIKey
-
KOEUOFPEZFUWRF-LJQANCHMSA-N
Specifications
- MW (average)
- 455.5084
- Formula
- C26H25N5O3
- CAS No.
- 1971920-73-6
- Physical state
- Solid
- Color
- Off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO