hDHODH-IN-8 free base
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase.
For research use only. Not for human or veterinary use.
Target
Dihydroorotate Dehydrogenase
Research area
Inflammation/Immunology
Purity >98%
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hDHODH-IN-8 structure
CAS No.: 2757405-31-3
Pack sizes & pricing
Description
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH). hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility.
Biological activity
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma.
Identifiers
- SMILES
-
FC1=C(NC(/C(C#N)=C(O)/C)=O)C=C(O[C@H](C(F)(F)F)C)C(C(NC2=C(F)C=CC=C2F)=O)=C1 - InChIKey
-
BIDNHWHAWYEYKL-JMZICWNOSA-N
Specifications
- MW (average)
- 487.3519
- Formula
- C21H15F6N3O4
- CAS No.
- 2757405-31-3
- Physical state
- Solid
- Color
- White to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO 25 mg/mL DMF 10 mg/mL
Documents
References
[1]. Li C, et al. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem. 2021;64(24):18175-18192.