VT-105 free base · Synonyms: VT 105 · VT105

VT-105 is a potent and selective TEAD Auto-palmitoylation inhibitor of Proliferation.

For research use only. Not for human or veterinary use.

Target YAP

Research area Cancer

Purity >99% Stock Inquire

Data Sheet SDS COA

VT-105 structure

CAS No.: 2417718-38-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
5 mg	USD 480.00	BP-02012-5mg	In stock	Get quote
10 mg	USD 650.00	BP-02012-10mg	In stock	Get quote
25 mg	USD 850.00	BP-02012-25mg	In stock	Get quote
50 mg	USD 1,150.00	BP-02012-50mg	In stock	Get quote
100 mg	USD 1,550.00	BP-02012-100mg	In stock	Get quote
250 mg	USD 2,050.00	BP-02012-250mg	In stock	Get quote
500 mg	USD 2,650.00	BP-02012-500mg	In stock	Get quote
1 g	Inquire	BP-02012-1g	In stock	Inquire

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Description

VT-105 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT105 is a more soluble analog of VT104.

Identifiers

SMILES: O=C(C1=CC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2N=C1)N[C@H](C4=NC=CC=C4)C
InChIKey: FUKXXBXVSANFJK-HNNXBMFYSA-N

Specifications

MW (average): 421.4144
Formula: C₂₄H₁₈F₃N₃O
CAS No.: 2417718-38-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO: ≥ 100 mg/mL

Documents

References

[1]. Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. doi: 10.1158/1535-7163.MCT-20-0717. Epub 2021 Apr 13. PMID: 33850002.

[2]. Hu L, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210.

Same target

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Same research area

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