VT-104 free base · Synonyms: VT 104 · VT104

VT104 is a potent and orally active YAP/TAZ inhibitor.

For research use only. Not for human or veterinary use.

Target YAP

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

VT-104 structure

CAS No.: 2417718-25-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 500.00	BP-02359-100mg	In stock	Get quote
250 mg	USD 800.00	BP-02359-250mg	In stock	Get quote
500 mg	USD 1,300.00	BP-02359-500mg	In stock	Get quote
1 g	USD 2,000.00	BP-02359-1g	In stock	Get quote
5 g	Inquire	BP-02359-5g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

Biological activity

In Vitro VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line In Vivo VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts

Identifiers

SMILES: O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C
InChIKey: AAZUPSFRSHFTGV-INIZCTEOSA-N

Specifications

MW (average): 420.4264
Formula: C₂₅H₁₉F₃N₂O
CAS No.: 2417718-25-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO 100 mg/mL

Documents

References

[1]. Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998.

[2]. Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10(10):2715.

Same target

Search YAP

Same research area

Search Cancer