AOH1160 free base · Synonyms: AOH-1160 · AOH 1160

AOH1160 is a potent oral small molecule proliferating cell nuclear antigen inhibitor.

For research use only. Not for human or veterinary use.

Target DNA/RNA Synthesis Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AOH1160 structure

CAS No.: 2089314-57-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 330.00	BP-02411-100mg	In stock	Get quote
250 mg	USD 660.00	BP-02411-250mg	In stock	Get quote
500 mg	USD 1,056.00	BP-02411-500mg	In stock	Get quote
1 g	USD 1,690.00	BP-02411-1g	In stock	Get quote
2 g	USD 2,700.00	BP-02411-2g	In stock	Get quote
3 g	USD 3,245.00	BP-02411-3g	In stock	Get quote
5 g	USD 4,325.00	BP-02411-5g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis .

Biological activity

In Vitro AOH1160 (500 nM, 48 h) can lead to tumor cell cycle arrest and induce tumor cell apoptosis. In Vivo AOH1160 (40 mg/kg, gavage once a day) can inhibit the growth of breast cancer and small cell lung cancer in mice.

Identifiers

SMILES: O=C(C1=C2C=CC=CC2=CC=C1)NCC(NC3=CC=CC=C3OC4=CC=CC=C4)=O
InChIKey: COPRLRLXDBSLET-UHFFFAOYSA-N

Specifications

MW (average): 396.4379
Formula: C₂₅H₂₀N₂O₃
CAS No.: 2089314-57-6
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065.

Same target

Search DNA/RNA Synthesis

Same research area

Search Cancer