Tagtociclib hydrate other · Synonyms: PF-07104091 hydrate

PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor.

For research use only. Not for human or veterinary use.

Target CDK GSK-3

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Tagtociclib hydrate structure

CAS No.: 2733575-91-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 898.00	BP-02225A-25mg	In stock	Get quote
50 mg	USD 1,580.00	BP-02225A-50mg	In stock	Get quote
100 mg	USD 2,500.00	BP-02225A-100mg	In stock	Get quote

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Related forms

BP-02225 — PF-07104091

Description

PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2).

Biological activity

PF-07104091 hydrate (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM, respectively

Identifiers

SMILES: O=C(C1=CC(COC)=NN1C)NC2=NNC([C@](CC3)([H])C[C@@H]3OC(NC(C)C)=O)=C2.[H]O[H]
InChIKey: CFGMPDNYFGKCIR-DSHXVJGRSA-N

Specifications

MW (average): 422.4787
Formula: C₁₉H₃₀N₆O₅
CAS No.: 2733575-91-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture and light

Solubility

Soluble in DMSO : ≥ 100 mg/mL

Documents

References

[1].Douglas Carl BEHENNA, et al. Cdk2 inhibitors. WO2020157652A2.

Same target

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