Dihydro Daidzein free base

Dihydrodaidzein is a dietary phytoestrogen.

For research use only. Not for human or veterinary use.

Target Endogenous Metabolite Apoptosis NF-κB p38 MAPK

Research area Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Dihydro Daidzein structure

CAS No.: 17238-05-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 485.00	BP-02288-1g	In stock	Get quote
5 g	USD 985.00	BP-02288-5g	In stock	Get quote
10 g	USD 1,385.00	BP-02288-10g	In stock	Get quote
25 g	USD 2,385.00	BP-02288-25g	In stock	Get quote

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Description

Dihydrodaidzein is a dietary phytoestrogen. Dihydrodaidzein possesses functions including antioxidation, inhibition of DNA oxidative damage, regulation of lipid metabolism and maintenance of intestinal flora stability. Dihydrodaidzein induces apoptosis, regulates immune responses, modulates tumor-related factors, activates the Bmp-2 signaling pathway, inhibits NF-κB and MAPK, and exhibits anti-inflammatory activity. Dihydrodaidzein can be used in research related to cancer, cardiovascular diseases, osteoporosis and inflammatory diseases[1][2][3][4][5].

Biological activity

In Vitro Dihydrodaidzein, which is obtained as a racemic mixture through the conversion of Daidzein by cell extracts of Slackia isoflavoniconvertens, can be further converted into Equol ((-)-(S)-Equol). Dihydrodaidzein can be absorbed and converted into Equol ((-)-(S)-Equol) by bacteria of the genus Lactococcus. Dihydrodaidzein exhibits high effective permeability in artificial membrane and Caco-2 monolayer assays, indicating its superior intestinal permeability. Dihydrodaidzein promotes osteogenesis in MC3T3-E1 cells via the Bmp2 pathway and inhibits osteoclastogenesis in RAW 264.7 cells by suppressing the NF-κB and MAPK pathways. Dihydrodaidzein possesses favorable water solubility (0.14 g/L), exhibits definite solubility in various organic solvents and alkaline solutions, and has a pKa value of 7.71.

Identifiers

SMILES: O=C1C(C2=CC=C(O)C=C2)COC3=CC(O)=CC=C13
InChIKey: JHYXBPPMXZIHKG-UHFFFAOYSA-N

Specifications

MW (average): 256.2534
Formula: C₁₅H₁₂O₄
CAS No.: 17238-05-0
Physical state: Solid
Color: Off-white to gray
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Schröder C, et al. Identification and expression of genes involved in the conversion of daidzein and genistein by the equol-forming bacterium Slackia isoflavoniconvertens. Applied and environmental microbiology. 2013 Jun;79(11):3494-502.

[2].Franke AA, et al. Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Sep 25;777(1-2):45-59.

[3].Ubaid M, et al. Daidzein from Dietary Supplement to a Drug Candidate: An Evaluation of Potential. ACS omega. 2023 Sep 12;8(36):32271-32293.

[4].Shimada Y, et al. Cloning and expression of a novel NADP(H)-dependent daidzein reductase, an enzyme involved in the metabolism of daidzein, from equol-producing Lactococcus strain 20-92. Applied and environmental microbiology. 2010 Sep;76(17):5892-901.

[5].Zou P, et al. Advances on resource, biosynthesis pathway, bioavailability, and bioactivity of dihydrodaidzein. Phytochem Rev. 2025;24:3915-3940.

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