IQ-3 free base · Synonyms: IQ 3 · IQ3
IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase family.
For research use only. Not for human or veterinary use.
Target
JNK
Research area
Inflammation/Immunology
Purity >98%
Stock Inquire
IQ-3 structure
CAS No.: 312538-03-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 400.00 | BP-02153-100mg | In stock | Get quote |
| 250 mg | USD 780.00 | BP-02153-250mg | In stock | Get quote |
| 500 mg | USD 1,200.00 | BP-02153-500mg | In stock | Get quote |
| 1 g | USD 1,900.00 | BP-02153-1g | In stock | Get quote |
| 2 g | USD 3,000.00 | BP-02153-2g | In stock | Get quote |
| 3 g | USD 3,980.00 | BP-02153-3g | In stock | Get quote |
| 5 g | Inquire | BP-02153-5g | In stock | Inquire |
Description
IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3.
Biological activity
In Vitro IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively. IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.
Identifiers
- SMILES
-
O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5 - InChIKey
-
WBSWWONMTZEOGS-PTGBLXJZSA-N
Specifications
- MW (average)
- 341.3196
- Formula
- C20H11N3O3
- CAS No.
- 312538-03-7
- Physical state
- Solid
- Color
- Off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
Documents
References
[1].Igor A Schepetkin, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81(6):832-45.