IQ-3 free base · Synonyms: IQ 3 · IQ3

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase family.

For research use only. Not for human or veterinary use.

Target JNK

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

IQ-3 structure

CAS No.: 312538-03-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 400.00	BP-02153-100mg	In stock	Get quote
250 mg	USD 780.00	BP-02153-250mg	In stock	Get quote
500 mg	USD 1,200.00	BP-02153-500mg	In stock	Get quote
1 g	USD 1,900.00	BP-02153-1g	In stock	Get quote
2 g	USD 3,000.00	BP-02153-2g	In stock	Get quote
3 g	USD 3,980.00	BP-02153-3g	In stock	Get quote

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Description

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3.

Biological activity

In Vitro IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively. IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells.

Identifiers

SMILES: O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5
InChIKey: WBSWWONMTZEOGS-PTGBLXJZSA-N

Specifications

MW (average): 341.3196
Formula: C₂₀H₁₁N₃O₃
CAS No.: 312538-03-7
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1].Igor A Schepetkin, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81(6):832-45.

Same research area

Search Inflammation/Immunology