Bucolome free base · Synonyms: Bucolom | Paramidin | Paramidine
Bucolome is a CYP2C9 inhibitor.
For research use only. Not for human or veterinary use.
Target
Cytochrome P450
Research area
Inflammation/Immunology
Purity >98%
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Bucolome structure
CAS No.: 841-73-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 350.00 | BP-02088-25mg | In stock | Get quote |
| 50 mg | USD 560.00 | BP-02088-50mg | In stock | Get quote |
| 100 mg | USD 900.00 | BP-02088-100mg | In stock | Get quote |
| 250 mg | USD 180.00 | BP-02088-250mg | In stock | Get quote |
| 500 mg | USD 2,880.00 | BP-02088-500mg | In stock | Get quote |
| 1 g | USD 4,600.00 | BP-02088-1g | In stock | Get quote |
| 2 g | Inquire | BP-02088-2g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Bucolome is a CYP2C9 inhibitor, used as an uricosuric agent or anti-inflammatory agent.
Biological activity
Bucolome is a potent mixed-type inhibitor for (S)-warfarin 7-hydroxylation, with Ki of 8.2 and 20.2 μM, respectively
Identifiers
- SMILES
-
O=C1NC(C(CCCC)C(N1C2CCCCC2)=O)=O - InChIKey
-
DVEQCIBLXRSYPH-UHFFFAOYSA-N
Specifications
- MW (average)
- 266.3361
- Formula
- C14H22N2O3
- CAS No.
- 841-73-6
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 100 mg/mL
Documents
References
[1]. Takahashi H, et al. Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance. Drug Metab Dispos. 1999 Oct;27(10):1179-86.