TAK-242 free base · Synonyms: Resatorvid | CLI-095

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor and plays pivotal role in various inflammatory diseases.

For research use only. Not for human or veterinary use.

Target Toll-like Receptor (TLR) Autophagy

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

TAK-242 structure

CAS No.: 243984-11-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 450.00	BP-02349-100mg	In stock	Get quote
250 mg	USD 750.00	BP-02349-250mg	In stock	Get quote
500 mg	USD 1,200.00	BP-02349-500mg	In stock	Get quote
1 g	USD 1,850.00	BP-02349-1g	In stock	Get quote
2 g	USD 2,900.00	BP-02349-2g	In stock	Get quote
5 g	Inquire	BP-02349-5g	In stock	Inquire

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Description

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor and plays pivotal role in various inflammatory diseases.

Biological activity

Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases.

Identifiers

SMILES: O=S([C@H]1C(C(OCC)=O)=CCCC1)(NC2=CC=C(C=C2Cl)F)=O
InChIKey: LEEIJTHMHDMWLJ-CQSZACIVSA-N

Specifications

MW (average): 361.8160
Formula: C₁₅H₁₇ClFNO₄S
CAS No.: 243984-11-4
Physical state: Solid
Color: Off-white to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

CoA On request
Handling Instructions

Same target

Search Toll-like Receptor (TLR)

Same research area

Search Inflammation/Immunology