Casein Kinase II Inhibitor IV free base

Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor.

For research use only. Not for human or veterinary use.

Target Casein Kinase

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Casein Kinase II Inhibitor IV structure

CAS No.: 863598-09-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 798.00	BP-01673-250mg	In stock	Get quote
500 mg	USD 1,150.00	BP-01673-500mg	In stock	Get quote
1 g	USD 1,850.00	BP-01673-1g	In stock	Get quote
5 g	Inquire	BP-01673-5g	In stock	Inquire

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Description

Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM. Casein Kinase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer.

Biological activity

In Vitro Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.

Identifiers

SMILES: N#CCCC1=CC=CC(N2C=CC3=CN=C(NC4=CC(OC)=C(OC)C(OC)=C4)N=C32)=C1
InChIKey: KKVZKYOBQGDKIB-UHFFFAOYSA-N

Specifications

MW (average): 429.4711
Formula: C₂₄H₂₃N₅O₃
CAS No.: 863598-09-8
Physical state: Solid
Color: light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 33.33 mg/mL

Documents

References

[1]. Hong J, et al. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. ACS Chem Biol. 2007 Mar 20;2(3):171-5.

Same target

Search Casein Kinase

Same research area

Search Metabolic Disease