TSPO ligand-1 free base

TSPO ligand-1 is the ligand of AUTAC4.

For research use only. Not for human or veterinary use.

Target Ligands for Target Protein for PROTAC Autophagy

Research area Others Neurological Disease Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

TSPO ligand-1 structure

CAS No.: 4560-08-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 480.00	BP-02161-250mg	In stock	Get quote
500 mg	USD 750.00	BP-02161-500mg	Inquire	Get quote
1 g	USD 1,200.00	BP-02161-1g	Inquire	Get quote
2 g	USD 1,950.00	BP-02161-2g	In stock	Get quote
3 g	USD 2,800.00	BP-02161-3g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

TSPO ligand-1 is the ligand of AUTAC4 that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal.

Biological activity

In Vitro TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice. TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells. TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.

Identifiers

SMILES: O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl
InChIKey: DREHVYWKTXGDBS-UHFFFAOYSA-N

Specifications

MW (average): 283.7090
Formula: C₁₆H₁₀ClNO₂
CAS No.: 4560-08-1
Physical state: Solid
Color: Light yellow to green yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃, protect from light, stored under nitrogen; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

[2]. Tina Notter, et al. Neuronal activity increases translocator protein (TSPO) levels. Mol Psychiatry. 2021 Jun;26(6):2025-2037. doi: 10.1038/s41380-020-0745-1. Epub 2020 May 12.

[3]. Benjamin B Tournier, et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease. J Alzheimers Dis. 2020;77(3):1043-1056. doi: 10.3233/JAD-200136.

[4]. Lan N Tu, et al. Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells. Endocrinology. 2016 Mar;157(3):1110-21. doi: 10.1210/en.2015-1795. Epub 2016 Jan 7.

Same target

Search Ligands for Target Protein for PROTAC

Same research area

Search Others