3-Pyridazinecarboxamide, 6-chloro-N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]- free base · Synonyms: 2505498-73-5

AR ligand-30 is a target protein ligand targeting AR, which can be used in studies related to PROTAC synthesis, such as serving as the target…

For research use only. Not for human or veterinary use.

Target Ligands for Target Protein for PROTAC Androgen Receptor

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

3-Pyridazinecarboxamide, 6-chloro-N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]- structure

CAS No.: 2505498-73-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 380.00	BP-02027-1g	In stock	Get quote
5 g	USD 1,380.00	BP-02027-5g	In stock	Get quote

Need another size or custom synthesis? Request a quote.

Description

AR ligand-30 is a target protein ligand targeting AR, which can be used in studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC Bavdegalutamide.

Biological activity

In Vitro AR ligand-30 serves as a target protein ligand for the PROTAC Bavdegalutamide. Bavdegalutamide (ARV-110) is an orally active PROTAC degrader that promotes ubiquitination and degradation of AR, and it can be used in prostate cancer research.

Identifiers

SMILES: ClC(C=C1O[C@@H](CC2)CC[C@H]2NC(C3=CC=C(N=N3)Cl)=O)=C(C=C1)C#N
InChIKey: ZBLXGHCGQZWSTO-JOCQHMNTSA-N

Specifications

MW (average): 391.2510
Formula: C₁₈H₁₆Cl₂N₄O₂
CAS No.: 2505498-73-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 50 mg/mL

Documents

References

[1]. Taavi Neklesa, et al. ARV-110: An androgen receptor PROTAC degrader for prostate cancer. American Association for Cancer Research. 2018. 78 (13): pp. 5236.

[2]. Taavi K Neklesa,et al. ARV-110: an oral androgen receptor PROTAC degrader for prostate cancer. GU ASCO 2019

Same target

Search Ligands for Target Protein for PROTAC

Same research area

Search Cancer