BP-02501 free base · Synonyms: BP 02501 · BP02501

Nedisertib is an orally active selective DNA-dependent protein kinase inhibitor.

For research use only. Not for human or veterinary use.

Target DNA-PK BCRP

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BP-02501 structure

CAS No.: 1637542-33-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 660.00	BP-02501-250mg	In stock	Get quote
500 mg	USD 998.00	BP-02501-500mg	In stock	Get quote
1 g	USD 1,698.00	BP-02501-1g	In stock	Get quote
2 g	USD 2,998.00	BP-02501-2g	In stock	Get quote
5 g	Inquire	BP-02501-5g	In stock	Inquire

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Description

Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .

Biological activity

Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of <3 nM.

Identifiers

SMILES: COC1=NN=C(C=C1)[C@@H](O)C1=CC(=C(F)C=C1Cl)C1=C2C=CC(=CC2=NC=N1)N1CCOCC1
InChIKey: MOWXJLUYGFNTAL-DEOSSOPVSA-N

Specifications

MW (average): 481.9070
Formula: C₂₄H₂₁ClFN₅O₃
CAS No.: 1637542-33-6
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, protect from light, stored under nitrogen

Solubility

Soluble in DMSO

Documents

References

[1]. Wu ZX, et al. M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells. Front Oncol. 2020 May 12;10:674.

[2]. L. Damstrup, et al. M3814, a DNA-dependent Protein Kinase Inhibitor (DNA-PKi), Potentiates the Effect of Ionizing Radiation (IR) in Xenotransplanted Tumors in Nude Mice. IJROBP. 2016; 94, 940-941.

[3]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1. 2014-11-20.

Same target

Search DNA-PK

Same research area

Search Cancer