IC 86621 free base · Synonyms: IC-86621 · IC86621

IC 86621 is a potent DNA-dependent protein kinase inhibitor.

For research use only. Not for human or veterinary use.

Target DNA-PK Apoptosis

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

IC 86621 structure

CAS No.: 404009-40-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 330.00	BP-02437-250mg	In stock	Get quote
500 mg	USD 530.00	BP-02437-500mg	In stock	Get quote
1 g	USD 840.00	BP-02437-1g	In stock	Get quote
2 g	USD 1,350.00	BP-02437-2g	In stock	Get quote
3 g	USD 1,620.00	BP-02437-3g	In stock	Get quote
5 g	USD 2,160.00	BP-02437-5g	In stock	Get quote
10 g	USD 3,460.00	BP-02437-10g	In stock	Get quote

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Description

IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis .

Biological activity

In Vitro IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12. IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis.

Identifiers

SMILES: CC(C1=CC=C(N2CCOCC2)C=C1O)=O
InChIKey: YHKSBKQXCWHTQL-UHFFFAOYSA-N

Specifications

MW (average): 221.2524
Formula: C₁₂H₁₅NO₃
CAS No.: 404009-40-1
Physical state: Solid
Color: Light yellow to brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: 4°C, sealed storage, away from moisture

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1].Chandra G, et al. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Arch Pharm Res. 2012 Mar;35(4):639-45.

[2].Shao L, et al. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010 Oct;2(10):415-27.

Same target

Search DNA-PK

Same research area

Search Inflammation/Immunology