DNA-PK-IN-12 free base

DNA-PK-IN-12 is an oral active DNA-PK inhibitor.

For research use only. Not for human or veterinary use.

Target DNA-PK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

DNA-PK-IN-12 structure

CAS No.: 2792146-91-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 508.00	BP-00815-25mg	In stock	Get quote
50 mg	USD 812.00	BP-00815-50mg	In stock	Get quote
100 mg	USD 1,300.00	BP-00815-100mg	In stock	Get quote
500 mg	Inquire	BP-00815-500mg	Inquire	Inquire

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Description

DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC50 of 33.28 μM, and shows antitumor activity in vivo .

Identifiers

SMILES: O=C1N(C2=CN=C(N=C2N1C3CCOCC3)NC=4C=NC(=CC4C)C=5C=NN(C5)C)C
InChIKey: GDKSDPBBGUPQCM-UHFFFAOYSA-N

Specifications

MW (average): 420.4677
Formula: C₂₁H₂₄N₈O₂
CAS No.: 2792146-91-7
Physical state: Solid
Color: Light brown to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Liu K, et al. Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. J Med Chem. Published online December 20, 2023.

Same target

Search DNA-PK

Same research area

Search Cancer