AZD-7648 free base · Synonyms: AZD 7648 · AZD7648

AZD-7648 is a potent and selective DNA-PK inhibitor.

For research use only. Not for human or veterinary use.

Target DNA-PK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AZD-7648 structure

CAS No.: 2230820-11-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 480.00	BP-01991-250mg	In stock	Get quote
500 mg	USD 768.00	BP-01991-500mg	In stock	Get quote
1 g	USD 1,230.00	BP-01991-1g	In stock	Get quote
5 g	Inquire	BP-01991-5g	In stock	Inquire

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Description

AZD-7648 is a potent and selective DNA-PK inhibitor.

Biological activity

In Vitro AZD7648 (0-30 μM) is a potent radiosensitizer. AZD7648 (3 μM) increases sensitivity to Doxorubicin. AZD7648 (0.6 μM) enhances the activity of PARP inhibitor Olaparib. In Vivo AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression.

Identifiers

SMILES: CN1C(=O)N(C2CCOCC2)C2=NC(NC3=CN4N=CN=C4C=C3C)=NC=C12
InChIKey: XISVSTPEXYIKJL-UHFFFAOYSA-N

Specifications

MW (average): 380.4038
Formula: C₁₈H₂₀N₈O₂
CAS No.: 2230820-11-6
Physical state: Solid
Color: White to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO; need ultrasonic and heat

Documents

References

[1]. Fok JHL, et al. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065.

Same target

Search DNA-PK

Same research area

Search Cancer