Decernotinib free base · Synonyms: VX-509

Decernotinib is a potent, orally active JAK3 inhibitor.

For research use only. Not for human or veterinary use.

Target JAK

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

Decernotinib structure

CAS No.: 944842-54-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 450.00	BP-02498-100mg	In stock	Get quote
250 mg	USD 798.00	BP-02498-250mg	In stock	Get quote
500 mg	USD 1,398.00	BP-02498-500mg	In stock	Get quote
1 g	USD 2,398.00	BP-02498-1g	In stock	Get quote
2 g	Inquire	BP-02498-2g	In stock	Inquire

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Description

Decernotinib is a potent, orally active JAK3 inhibitor, with Kis of 2.5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2, respectively.

Biological activity

Decernotinib is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. Decernotinib (VX-509) potently inhibits JAK3 in enzyme assays (Ki =2.5 nM + 0.7 nM) and cellular assays dependent on JAK3 activity (IC50 range, 50-170 nM), with limited or no measurable potency against other JAK isotypes or non-JAK kinases.

Identifiers

SMILES: CC[C@@](C)(NC1=NC(=NC=C1)C1=CNC2=C1C=CC=N2)C(=O)NCC(F)(F)F
InChIKey: ASUGUQWIHMTFJL-QGZVFWFLSA-N

Specifications

MW (average): 392.3783
Formula: C₁₈H₁₉F₃N₆O
CAS No.: 944842-54-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture

Solubility

Soluble in DMSO;H2O

Documents

References

[1]. Mahajan S, et al. VX-509 is a potent and selective Janus kinase 3 (JAK3) inhibitor that attenuates inflammation in animal models of autoimmune disease. J Pharmacol Exp Ther. 2015 Mar 11. pii: jpet.114.221176.

Same target

Search JAK

Same research area

Search Inflammation/Immunology