ZM 449829 free base · Synonyms: ZM-449829 · ZM449829

ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3.

For research use only. Not for human or veterinary use.

Target JAK EGFR

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

ZM 449829 structure

CAS No.: 4452-06-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 360.00	BP-01476-1g	In stock	Get quote
5 g	USD 1,260.00	BP-01476-5g	In stock	Get quote
10 g	USD 1,960.00	BP-01476-10g	In stock	Get quote
25 g	Inquire	BP-01476-25g	In stock	Inquire
50 g	Inquire	BP-01476-50g	In stock	Inquire

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Description

ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3 .

Biological activity

In Vitro ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0). ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation

Identifiers

SMILES: C=CC(C1=CC=C2C=CC=CC2=C1)=O
InChIKey: FOTCGZPFSUWZBN-UHFFFAOYSA-N

Specifications

MW (average): 182.2179
Formula: C₁₃H₁₀O
CAS No.: 4452-06-6
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 year; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Brown GR, et, al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 2010(6)575-9.

[2]. Orange JS, et, al. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Apr; 121(4): 1535-48.

Same target

Search JAK

Same research area

Search Inflammation/Immunology