LY-3177833 free base · Synonyms: LY 3177833 · LY3177833

LY3177833 is an orally active CDC7 and pMCM2 inhibitor.

For research use only. Not for human or veterinary use.

Target CDK

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

LY-3177833 structure

CAS No.: 1627696-51-8

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 590.00	BP-02485-100mg	In stock	Get quote
250 mg	USD 1,180.00	BP-02485-250mg	In stock	Get quote
500 mg	USD 1,890.00	BP-02485-500mg	In stock	Get quote
1 g	USD 3,020.00	BP-02485-1g	In stock	Get quote
2 g	USD 4,830.00	BP-02485-2g	In stock	Get quote
3 g	Inquire	BP-02485-3g	In stock	Inquire

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Description

LY3177833 (Example 4) is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 is a senescence inducer .

Biological activity

In Vitro LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells. In Vivo LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation.

Identifiers

SMILES: C[C@]1(NC(=O)C2=CC(=CC=C12)C1=CNN=C1)C1=NC=NC=C1F
InChIKey: KNLVLWZENYQYRT-MRXNPFEDSA-N

Specifications

MW (average): 309.2978
Formula: C₁₆H₁₂FN₅O
CAS No.: 1627696-51-8
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year;

Solubility

Soluble in DMSO

Documents

References

[1].Robert Dean Dally, et al. CDC7 Inhibitors. Patent WO2014143601A1.

[2].Li X, et al. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chem Sci. 2020 Jun 17;11(28):7292-7301.

Same target

Search CDK

Same research area

Search Cancer