SSK1 free base · Synonyms: SSK-1 · SSK 1

SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation.

For research use only. Not for human or veterinary use.

Target p38 MAPK Apoptosis

Research area Inflammation/Immunology

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Data Sheet SDS COA

SSK1 structure

CAS No.: 2629250-69-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 420.00	BP-02398-10mg	In stock	Get quote
25 mg	USD 840.00	BP-02398-25mg	In stock	Get quote
50 mg	USD 1,340.00	BP-02398-50mg	In stock	Get quote
100 mg	USD 2,150.00	BP-02398-100mg	In stock	Get quote
250 mg	USD 4,300.00	BP-02398-250mg	In stock	Get quote
500 mg	Inquire	BP-02398-500mg	In stock	Inquire

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Description

SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis .

Biological activity

In Vitro SSK1 (0.5 μM; 12-72 hours) activates the phosphorylation levels of both p38 MAPK and MKK3/MKK6 in senescent cells. SSK1 kills senescent cells through the activation of the p38 MAPK signaling pathway. SSK1 is able to induce mitochondrial DNA damage in senescent cells. ? SSK1 (0.01-1 μM; 3 days) selectively and potently eliminates β-galactosidase-positive senescent cells within a wide therapeutic window. In Vivo SSK1 (0.5 mg/kg; i.p.; two days every week; for four weeks) could eliminate senescent cells and decrease senescence-associated markers in lung-injured mice. ? In aged mice (20-month-old), SSK1 (0.5 mg/kg; 3 days every 2 weeks for 8 weeks) effectively clears senescent cells in different tissues, decreases the senescence- and age-associated gene signatures, attenuates low-grade local and systemic inflammation, and restores physical function.

Identifiers

SMILES: CC(O[C@H]([C@H]([C@H]1OC(C)=O)OC(C)=O)[C@@H](O[C@@H]1COC(C)=O)OC(C=CC(COC(NC(C=CN2[C@](C(F)([C@@H]3O)F)([H])O[C@@H]3CO)=NC2=O)=O)=C4)=C4[N+]([O-])=O)=O
InChIKey: DLQYTWCQXUJEML-XERWOCHESA-N

Specifications

MW (average): 788.6145
Formula: C₃₁H₃₄F₂N₄O₁₈
CAS No.: 2629250-69-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Yusheng Cai, et al. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res. 2020 Jul;30(7):574-589.

Same target

Search p38 MAPK

Same research area

Search Inflammation/Immunology