Nitecapone free base · Synonyms: OR-462
Nitecapone is an orally active and short-acting catechol-O-methyltransferase inhibitor.
For research use only. Not for human or veterinary use.
Nitecapone structure
CAS No.: 116313-94-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 1 g | USD 598.00 | BP-01638-1g | In stock | Get quote |
| 2 g | USD 1,065.00 | BP-01638-2g | In stock | Get quote |
| 3 g | USD 1,476.00 | BP-01638-3g | In stock | Get quote |
| 5 g | USD 2,332.00 | BP-01638-5g | In stock | Get quote |
| 10 g | Inquire | BP-01638-10g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation.
Biological activity
In Vitro Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45% In Vivo Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats
Identifiers
- SMILES
-
CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O - InChIKey
-
UPMRZALMHVUCIN-UHFFFAOYSA-N
Specifications
- MW (average)
- 265.2188
- Formula
- C12H11NO6
- CAS No.
- 116313-94-1
- Physical state
- Solid
- Color
- light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4℃, 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 50 mg/mL