Mirabegron free base
Mirabegron is a selective β3-adrenoceptor agonist.
For research use only. Not for human or veterinary use.
Mirabegron structure
CAS No.: 223673-61-8
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 480.00 | BP-02316-100mg | In stock | Get quote |
| 250 mg | USD 950.00 | BP-02316-250mg | In stock | Get quote |
| 500 mg | USD 1,420.00 | BP-02316-500mg | In stock | Get quote |
| 1 g | USD 2,460.00 | BP-02316-1g | In stock | Get quote |
| 2 g | USD 3,930.00 | BP-02316-2g | In stock | Get quote |
| 3 g | USD 4,710.00 | BP-02316-3g | In stock | Get quote |
| 5 g | USD 6,290.00 | BP-02316-5g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
Biological activity
In Vitro Mirabegron (YM178) increases cyclic AMP accumulation in Chinese hamster ovary (CHO) cells expressing human β3-adrenoceptor (AR). EC50 value is 22.4 nM. EC50 values of Mirabegron for human β1- and β2-ARs are 10,000 nM or more, respectively. EC50 of Mirabegron in rat bladder strips precontracted with 10-6 M Carbachol (CCh) is 5.1 μM, whereas that in human bladder strips precontracted with 10-7 M CCh is 0.78 μM. Mirabegron concentration-dependently increases the accumulation of cAMP in CHO cells expressing human β3-ARs, with an EC50 value and I.A. of 22.4 nM and 0.8, respectively. Mirabegron has little agonistic effect on β1- and β2-ARs. Compared by EC50 value, Mirabegron is approximately one third as potent as isoproterenol. The maximal relaxant effects of Mirabegron are 94±1%, that of CCh, indicating that Mirabegron acts a full agonist in the rat bladder. The maximal relaxant effects of Mirabegron is 89.4±2.3%. In Vivo Mirabegron (YM178) produces a dose-dependent decrease in the frequency of rhythmic bladder contraction in anesthetized rats. In contrast, Mirabegron does not decrease the amplitude of rhythmic bladder contraction at up to 3 mg/kg i.v.. On the contrary, Oxybutynin significantly increases the frequency of rhythmic bladder contraction and decreased its amplitude at doses of 0.272 mg/kg i.v. or more.
Identifiers
- SMILES
-
NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1 - InChIKey
-
PBAPPPCECJKMCM-IBGZPJMESA-N
Specifications
- MW (average)
- 396.5060
- Formula
- C21H24N4O2S
- CAS No.
- 223673-61-8
- Physical state
- Solid
- Color
- white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4℃ 2 years; In solvent -20℃ 1 month;