LY 3000328 free base · Synonyms: LY3000328 | Z-FL-COCHO

LY 3000328 is a potent and selective Cathepsin S inhibitor.

For research use only. Not for human or veterinary use.

Target Cathepsin

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

LY 3000328 structure

CAS No.: 1373215-15-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 900.00	BP-02345-250mg	In stock	Get quote
500 mg	USD 1,450.00	BP-02345-500mg	In stock	Get quote
1 g	USD 2,150.00	BP-02345-1g	In stock	Get quote
5 g	USD 3,250.00	BP-02345-5g	In stock	Get quote

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Description

LY 3000328 (Z-FL-COCHO) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.

Biological activity

LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.

Identifiers

SMILES: CNC(=O)O[C@H]1COC2=CC=C(C=C2[C@@H]1NC(=O)C1=CC=C(F)C=C1)N1CCN(CC1)C1COC1
InChIKey: NDEBZCZEAVMSQF-GOTSBHOMSA-N

Specifications

MW (average): 484.5200
Formula: C₂₅H₂₉FN₄O₅
CAS No.: 1373215-15-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Jadhav PK, et al. Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42.

[2]. Payne CD, et al. Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects. Br J Clin Pharmacol. 2014 Dec;78(6):1334-42.

Same research area

Search Inflammation/Immunology