LHVS free base

LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor.

For research use only. Not for human or veterinary use.

Target Cathepsin Parasite

Research area Infection Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

LHVS structure

CAS No.: 170111-28-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 689.00	BP-02382-100mg	In stock	Get quote
250 mg	USD 1,198.00	BP-02382-250mg	In stock	Get quote
500 mg	USD 1,998.00	BP-02382-500mg	In stock	Get quote
1 g	Inquire	BP-02382-1g	In stock	Inquire
2 g	Inquire	BP-02382-2g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor. LHVS decreases actin ring formation. LHVS inhibits T. gondii invasion with an IC50 of 10 μM.

Biological activity

In Vivo LHVS (3-30 mg/kg, SC, once) shows anti-hyperalgesic effect in neuropathic rats. LHVS (30 nmol per rat, spinal delivery, daily) is antinociceptive in neuropathic rats. LHVS (1-50 nmol per rat, Intrathecal injection, daily) reverses established neuropathic mechanical hyperalgesia in 14-day neuropathic rats.

Identifiers

SMILES: O=C(N1CCOCC1)N[C@H](C(N[C@@H](CCC2=CC=CC=C2)/C=C/S(=O)(C3=CC=CC=C3)=O)=O)CC(C)C
InChIKey: YUMYYTORLYHUFW-MSKIIMLESA-N

Specifications

MW (average): 527.6750
Formula: C₂₈H₃₇N₃O₅S
CAS No.: 170111-28-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Wilson SR, et al. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23;284(4):2584-92.

[2]. Teo CF, et al.Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion. Antimicrob Agents Chemother. 2007 Feb;51(2):679-88.

[3]. Riese RJ, et al. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity. 1996 Apr;4(4):357-66.

[4]. Barclay J, et al. Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain. 2007 Aug;130(3):225-234.

[5]. Clark AK, et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10655-60.

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