Ispinesib free base · Synonyms: SB-715992

Ispinesib is a specific inhibitor of kinesin spindle protein.

For research use only. Not for human or veterinary use.

Target Kinesin Apoptosis Autophagy

Research area Inflammation/Immunology Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Ispinesib structure

CAS No.: 336113-53-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 458.00	BP-02344-250mg	In stock	Get quote
500 mg	USD 688.00	BP-02344-500mg	In stock	Get quote
1 g	USD 988.00	BP-02344-1g	In stock	Get quote
5 g	Inquire	BP-02344-5g	In stock	Inquire
10 g	Inquire	BP-02344-10g	In stock	Inquire

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Description

Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

Biological activity

Ispinesib (SB-715992), a potent and selective small molecule inhibitor of KSP, functions by inhibiting KSP ATPase and is 40000 times more selective for KSP compared to other kinesins. In preclinical studies, ispinesib inhibited growth in a wide range of human and murine cell lines with IC50 values of 1.2-9.5nm. Treatment of SKOV3 ovarian tumour cells in vitro with 20nm of ispinesib, or a Colo 205 colon cancer murine xenograft model with 30mgkg-1 of intraperitoneal ispinesib, caused mitotic arrest with cells demonstrating unseparated centrosomes and monopolar mitotic spindles. Tumour growth delay was observed in xenograft models of colon (HT29, Colo201, Colo205), non-small cell lung (Calu-3) and pancreatic (Panc-01) cancers.

Identifiers

SMILES: CC(C)[C@@H](N(CCCN)C(=O)C1=CC=C(C)C=C1)C1=NC2=CC(Cl)=CC=C2C(=O)N1CC1=CC=CC=C1
InChIKey: QJZRFPJCWMNVAV-HHHXNRCGSA-N

Specifications

MW (average): 517.0620
Formula: C₃₀H₃₃ClN₄O₂
CAS No.: 336113-53-2
Physical state: Solid
Color: white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4°C, protect from light <p>*In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)</p>

Solubility

Soluble in DMSO

Documents

References

[1]. Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47(11):3576-85.

[2]. Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16(2):566-76.

[3]. Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.

Same target

Search Kinesin

Same research area

Search Inflammation/Immunology