MTX-211 free base · Synonyms: MTX 211 · MTX211

MTX-211 is a dual inhibitor of EGFR.

For research use only. Not for human or veterinary use.

Target EGFR PI3K

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

MTX-211 structure

CAS No.: 1952236-05-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 598.00	BP-02340-100mg	In stock	Get quote
250 mg	USD 998.00	BP-02340-250mg	In stock	Get quote
500 mg	USD 1,698.00	BP-02340-500mg	In stock	Get quote
1 g	Inquire	BP-02340-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

MTX-211 is a dual inhibitor of EGFR and PI3K, which plays important roles in the progression of KRAS mutant colorectal cancer. MTX-211 has the potential for the treatment of KRAS mutant colorectal cancer.

Biological activity

In Vitro MTX-211 (MOL211) has inhibitory activity for both EGFR and PI3K Alpha with IC50 values of ＜100 nM

Identifiers

SMILES: CS(=O)(=O)NC1=C(Cl)N=CC(=C1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(F)C=C1
InChIKey: GUYKCXXNIKKSBC-UHFFFAOYSA-N

Specifications

MW (average): 478.3270
Formula: C₂₀H₁₄Cl₂FN₅O₂S
CAS No.: 1952236-05-3
Physical state: Solid
Color: Light yellow to brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 12.5 mg/mL

Documents

References

[1]. Small molecule inhibitors of egfr and pi3k. WO 2016100347 A2.

Same target

Search EGFR

Same research area

Search Cancer