Batefenterol Succinate free base · Synonyms: GSK-961081 Succinate | TD-5959 Succinate

Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3…

For research use only. Not for human or veterinary use.

Target Adrenergic Receptor mAChR

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Batefenterol Succinate structure

CAS No.: 945905-37-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 480.00	BP-02111-100mg	In stock	Get quote
250 mg	USD 780.00	BP-02111-250mg	In stock	Get quote
500 mg	USD 1,180.00	BP-02111-500mg	In stock	Get quote
1 g	USD 1,680.00	BP-02111-1g	In stock	Get quote
5 g	Inquire	BP-02111-5g	Inquire	Inquire

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Description

Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.

Identifiers

SMILES: OC(=O)CCC(O)=O.COC1=CC(NC(=O)CCN2CCC(CC2)OC(=O)NC2=CC=CC=C2C2=CC=CC=C2)=C(Cl)C=C1CNC[C@H](O)C1=C2C=CC(=O)NC2=C(O)C=C1
InChIKey: BDWHLFQPZLPCIZ-XLQCLRHOSA-N

Specifications

MW (average): 858.3320
Formula: C₄₄H₄₈ClN₅O₁₁
CAS No.: 945905-37-3
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Hegde SS, et al. Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. J Pharmacol Exp Ther. 2014 Oct;351(1):190-9.

[2]. Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD.

[3]. Hughes AD, et al. Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and β? agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD). J Med Chem. 2015 Mar 26;58(6):2609-22.

Same target

Search Adrenergic Receptor

Same research area

Search Neurological Disease