AKT Kinase Inhibitor free base

AKT Kinase Inhibitor is an Akt kinase inhibitor.

For research use only. Not for human or veterinary use.

Target Akt

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

AKT Kinase Inhibitor structure

CAS No.: 842148-40-7

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 400.00	BP-02280-10mg	In stock	Get quote
25 mg	USD 850.00	BP-02280-25mg	In stock	Get quote
50 mg	USD 1,450.00	BP-02280-50mg	In stock	Get quote
100 mg	USD 2,350.00	BP-02280-100mg	In stock	Get quote
250 mg	Inquire	BP-02280-250mg	In stock	Inquire

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Description

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

Biological activity

In Vitro The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion. In Vivo Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.

Identifiers

SMILES: CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N
InChIKey: LWLOLQIXHMFYND-UHFFFAOYSA-N

Specifications

MW (average): 357.3672
Formula: C₁₆H₁₉N₇O₃
CAS No.: 842148-40-7
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 year;

Solubility

soluble in DMSO

In vitro: DMSO : 20 mg/mL

Documents

References

[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

Same target

Search Akt

Same research area

Search Cancer