BiochemProbe — Life Science Research Reagents

M3541 free base · Synonyms: M-3541 · M 3541

M3541 is a potent, ATP-competitive and selective ATM inhibitor.

For research use only. Not for human or veterinary use.

Target ATM/ATR
Research area Cancer
Purity >98% Stock Inquire
Data Sheet SDS COA

M3541 structure

CAS No.: 1360628-91-6

Download structure (.mol)

Pack sizes & pricing

Size Price SKU Stock
100 mg USD 750.00 BP-02256-100mg In stock Get quote
250 mg USD 1,250.00 BP-02256-250mg In stock Get quote
500 mg USD 1,785.00 BP-02256-500mg In stock Get quote
1 g USD 2,285.00 BP-02256-1g In stock Get quote
3 g Inquire BP-02256-3g In stock Inquire
5 g Inquire BP-02256-5g In stock Inquire

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Description

M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC50 of 0.25 nM. M3541 shows remarkable selectivity against other protein kinases. M3541 suppresses double-strand breaks (DSB) repair and has antitumor activities.

Biological activity

M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC50 of 0.25 nM.

Identifiers

SMILES
N#CC1=CC=C(N(C2=C3C=NC4=CC(OC)=C(C5=CN(C)N=C5)C=C24)C(N3C)=O)C(F)=C1
InChIKey
OOCGUVCGJIUQKC-UHFFFAOYSA-N

Specifications

MW (average)
428.4185
Formula
C23H17FN6O2
CAS No.
1360628-91-6
Physical state
Solid
Color
White to light yellow
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage
Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro
DMSO : 4.55 mg/mL

Documents

References

[1]. Astrid Zimmermann, et al. A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies. Mol Cancer Ther. 2022 Jun 1;21(6):859-870.

Same target

Search ATM/ATR

Same research area

Search Cancer