USP30 inhibitor 18 free base
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30.
For research use only. Not for human or veterinary use.
USP30 inhibitor 18 structure
CAS No.: 2242582-40-5
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 450.00 | BP-02199-100mg | In stock | Get quote |
| 250 mg | USD 900.00 | BP-02199-250mg | In stock | Get quote |
| 500 mg | USD 1,440.00 | BP-02199-500mg | In stock | Get quote |
| 1 g | USD 2,300.00 | BP-02199-1g | In stock | Get quote |
| 2 g | USD 3,650.00 | BP-02199-2g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50=~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients[1][2].
Biological activity
In Vitro CMPD-39 (200 nM; 1-4 h) significantly enhances the ubiquitination levels of TOMM20 and SYNJ2BP in RPE1-YFP-PRKN and SHSY5Y cells, and dependents on USP30 expression. CMPD-39 (1 μM; 96 h) enhances basal mitophagy in SHSY5Y-mitoQC cells and significantly increases the number and area of ??mitophagosomes. CMPD-39 (200 nM-1 μM; 96 h) significantly enhances peroxisomal autophagy in U2OS-Keima-SKL cells and increases the number and area of ??peroxisomes.
Identifiers
- SMILES
-
CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@@H](NC(C2=CC=C(C=C2)F)=O)CC3=CC=CC=C3)=O)=O - InChIKey
-
NRHPFMQPXSSELC-QHCPKHFHSA-N
Specifications
- MW (average)
- 497.5820
- Formula
- C26H28FN3O4S
- CAS No.
- 2242582-40-5
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Solubility
soluble in DMSO