URB597 free base · Synonyms: URB-597 · URB 597

URB-597 is an orally bioavailable and selective FAAH inhibitor.

For research use only. Not for human or veterinary use.

Target FAAH Autophagy Mitophagy

Research area Neurological Disease

Purity >99% Stock Inquire

Data Sheet SDS COA

URB597 structure

CAS No.: 546141-08-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 260.00	BP-02128-500mg	In stock	Get quote
1 g	USD 485.00	BP-02128-1g	In stock	Get quote
2 g	USD 760.00	BP-02128-2g	In stock	Get quote
5 g	USD 1,540.00	BP-02128-5g	In stock	Get quote
10 g	USD 2,460.00	BP-02128-10g	In stock	Get quote

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Description

URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity .

Biological activity

In Vitro URB-597 (KDS-4103) prevents the FAAH-catalyzed hydrolysis of [3H]anandamide by primary cultures of rat cortical neurons with an IC50 value of ~0.50 nM. In Vivo URB-597 (KDS-4103) inhibits rat brain FAAH activity after intraperitoneal (i.p.) administration with a median inhibitory dose (ID50) of 0.15 mg/kg in wild-type mice (+/+) or FAAH-null mice (-/-). KDS-4103 (0.1-0.3 mg/kg, i.p.) elicits significant, anxiolytic-like, antidepressant-like and analgesic effects, which are prevented by treatment with CB1 receptor antagonists in rats and mice. KDS-4103 is orally available in rats and cynomolgus monkeys. URB-597 inhibits FAAH in the brain rapidly (1 h), sustains at >90% through 12 h and >60% through 24 h after an oral dose of 10 mg/kg.

Identifiers

SMILES: NC(=O)C1=CC(=CC=C1)C1=CC(OC(=O)NC2CCCCC2)=CC=C1
InChIKey: ROFVXGGUISEHAM-UHFFFAOYSA-N

Specifications

MW (average): 338.4003
Formula: C₂₀H₂₂N₂O₃
CAS No.: 546141-08-6
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 year;

Solubility

Soluble in DMSO/H2O

Documents

References

[1].Daniele Piomelli, et al. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. Spring 2006;12(1):21-38.

Same target

Search FAAH

Same research area

Search Neurological Disease