Miro1 Reducer salt form · hydrochloride · Parent Miro1 Reducer
Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts.
For research use only. Not for human or veterinary use.
Miro1 Reducer structure
CAS No.: 2624336-91-8
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 590.00 | BP-00148A-50mg | In stock | Get quote |
| 100 mg | USD 860.00 | BP-00148A-100mg | In stock | Get quote |
| 250 mg | USD 1,550.00 | BP-00148A-250mg | In stock | Get quote |
| 500 mg | USD 2,350.00 | BP-00148A-500mg | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts. Miro1 Reducer reduces the delayed mitophagy phenotype in PD fibroblasts. Miro1 Reducer reduces Miro1 protein levels in dose-dependent manner (IC50 = 7.8 mM).
Biological activity
In Vitro Miro1 Reducer (10 μM; 30 h) promotes Miro1 degradation following CCCP (HY-100941) treatment in fibroblasts from a sporadic PD patient. Miro1 Reducer (5 μM; 30 h) can completely rescue stress-induced neurodegeneration in dopaminergic neurons derived from PD patients. In Vivo Miro1 Reducer (2.5 μM) extends the shortened lifespan of SNCAA53T flies, rescues age-dependent dopaminergic neuron loss in three PD models, and ameliorates motor decline in LRRK2 and PINK1 models.
Identifiers
- SMILES
-
O=C(NC1=CC(F)=CC=C1)NC2=CC=C(NC3=NC=NC(N4C=NC=C4)=C3)C=C2.Cl - InChIKey
-
UKXRHSHXZHFFTA-UHFFFAOYSA-N
Specifications
- MW (average)
- 425.8470
- Formula
- C20H17ClFN7O
- CAS No.
- 2624336-91-8
- Physical state
- Solid
- Color
- Off-white to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, sealed storage, away from moisture; In solvent -20℃, 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 62.5 mg/mL