KSQ-4279 free base · Synonyms: USP1-IN-1 | Formula I

KSQ-4279 is a potent, selective, first-in-class inhibitor of USP1.

For research use only. Not for human or veterinary use.

Target Deubiquitinase PARP

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

KSQ-4279 structure

CAS No.: 2446480-97-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
250 mg	USD 425.00	BP-02019-250mg	In stock	Get quote
500 mg	USD 625.00	BP-02019-500mg	In stock	Get quote
1 g	USD 900.00	BP-02019-1g	In stock	Get quote
2 g	USD 1,450.00	BP-02019-2g	In stock	Get quote
5 g	USD 2,800.00	BP-02019-5g	In stock	Get quote
10 g	Inquire	BP-02019-10g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

KSQ-4279 is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.

Biological activity

USP1-IN-1 (USP1-IN-1, Formula I) is a first-in-class, selective allosteric USP1 small molecule inhibitor used in oncology research alone or in combination with PARP inhibition.

Identifiers

SMILES: FC(F)(C1=CN(C(C)C)C(C2=CC=C(CN3N=CC4=C3N=C(C5=C(C6CC6)N=CN=C5OC)N=C4)C=C2)=N1)F
InChIKey: KCBWAFJCKVKYHO-UHFFFAOYSA-N

Specifications

MW (average): 534.5356
Formula: C₂₇H₂₅F₃N₈O
CAS No.: 2446480-97-1
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO 80 mg/mL

Documents

References

[1]. Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569.

Same target

Search Deubiquitinase

Same research area

Search Cancer