TA-8995 free base · Synonyms: Obicetrapib | AMG-899

Obicetrapib is an orally active cholesteryl ester transfer protein inhibitor.

For research use only. Not for human or veterinary use.

Target CETP Apolipoprotein LPL Receptor LDLR

Research area Cardiovascular Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

TA-8995 structure

CAS No.: 866399-87-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 460.00	BP-02092-50mg	In stock	Get quote
100 mg	USD 736.00	BP-02092-100mg	In stock	Get quote
250 mg	USD 1,470.00	BP-02092-250mg	In stock	Get quote
500 mg	USD 2,360.00	BP-02092-500mg	In stock	Get quote
1 g	USD 3,770.00	BP-02092-1g	In stock	Get quote
2 g	USD 6,030.00	BP-02092-2g	In stock	Get quote

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Description

Obicetrapib (TA-8995; DEZ-001) is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib potently reduces atherogenic lipoproteins (such as LDL-C, ApoB, Lp (a)) and increases HDL-C. Obicetrapib can be used for the research of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD).

Biological activity

In Vitro Obicetrapib is a weak inducer of CYP3A4, but it has no significant effect on P-gp activity, and has good safety and tolerability.

Identifiers

SMILES: FC(F)(F)C1=CC(C(F)(F)F)=CC(CN(C2=NC=C(OCCCC(O)=O)C=N2)[C@@H]3C4=CC(C(F)(F)F)=CC=C4N([C@@H](C3)CC)C(OCC)=O)=C1
InChIKey: NRWORBQAOQVYBJ-GJZUVCINSA-N

Specifications

MW (average): 722.5980
Formula: C₃₂H₃₁F₉N₄O₅
CAS No.: 866399-87-3
Physical state: Solid
Color: white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years ; -20℃ 3 years ; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO ≥ 100 mg/mL

Documents

References

[1]. Kastelein JJP, et al. Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments. Curr Atheroscler Rep. 2024;26(2):35-44.

Same target

Search CETP

Same research area

Search Cardiovascular Disease